Boscolo Milano is truly a one-of-a-kind luxury design hotel under the management of Marriott, with one of the most fashionable addresses in Milan. Previously a bank, the property was transformed into a design hotel in 2009 by the same architect who renovated the Musée d’Orsay in Paris. In-the-know locals and sophisticated international travelers (families may not be comfortable here) book design-forward rooms, some of which have views of the Duomo from private balconies. A rooftop terrace, champagnerie (is that even a word in English?), and luxe spa are just a few of the features on offer. Breakfast, bike rentals, and Wi-Fi are free. Oh, and if you don't travel without your pup -- he or she is welcome here, free of charge. Compare rates at the nearby five-pearl Bulgari Milano if you prefer a bit more seclusion and the same level of luxury.