This historic city may be known for a certain charming, old-world downtown district, but the city also has a bustling business center filled with skyscrapers along a gorgeous river setting. And this big small-town has more to brag about than the scenery. Not only were poker and craps first played in this sometimes-sinful city, but the terms "Dixieland" and "Uncle Sam" also hail from here. Though this town is synonymous with the genre of music that it pioneered, it's also the site of the first opera to be performed in the U.S. back in 1796.
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Answer: New Orleans, the Crescent City (and, of course, the Big Easy)!