Downtown, Los Angeles, California
When the Biltmore opened, in 1923, it was the largest hotel west of Chicago. It quickly became a Southern California institution, hosting eight Academy Awards ceremonies in the '30s and '40s. But then the Oscars moved, and so did the rest of the action, and downtown Los Angeles devolved into a veritable ghost town, a designation it has only recently -- and only partially -- shed. The Biltmore no longer feels very glamorous, and yet it remains an icon: In 1969, it was designated a Historic Cultural Landmark by the city. And the hotel's press packet includes an exhaustive 11-page list of every movie (Wedding Crashers, Spider-Man, Ocean's Eleven), TV show (Mad Men, 24, The West Wing), miniseries, movie-of-the-week, reality show, commercial, music video, and photo shoot ever filmed on the premises. The Ghostbusters caught their first spook -- remember the slimer? -- in the Biltmore's ballroom.